Single-use platform to perform 4 continuous unit operations simultaneously
Automation controls flow from one step to the next and the mass flow rate of the entire process for purification of 50 to 500 L of cell culture per day.
The PAK system is designed for simultaneous operation of four sequential purification steps for monoclonal antibodies and other biopharmaceuticals: diafiltration, chromatography, viral inactivation, inline concentration, filtration
Synchronous operation is achieved with four control schemes: mass flow control, flow kit vessel level control, dual column vessel level control, and high-low level control
The flow kit vessel level control scheme continuously controls all upstream product and buffer pumps to ensure constant levels in the small break vessels between each process stage
Vessel high-low level control stops the pumps from running when vessels reach their minimum or maximum levels, in extreme circumstances
Multiple skids can be connected in series to operate an entire downstream process continuously, with required instrumentation and buffer management seamlessly integrated.
Realize over 4-fold productivity improvement compared to batch processes thanks to simultaneous operation of four sequential purification steps.
50% reduction in capital requirements compared to batch processes.
Up to 100 fold reduction in tank volumes thanks to simultaneous and serial operation.
All stages are controlled automatically and in accordance with CFR21 part11 with PurSyncTM dynamic automation package.
One of the best features of The PAK System is the easy setup.
The flow kit assembly combines all fluid management components and instrumentation into a single-use unit for quick installation.
Automation that is 21 CFR Part 11 compliant and product contact materials of construction that meet USP Class VI